Susan E. Hankinson, Meir J. Stampfer, Johanna M. Seddon, Graham A. Colditz, Bernard Rosner, Frank E. Speizer, Walter C. Willett
Abstract
Objective: To examine
prospectively the association between dietary intake of vitamins C and E,
carotene, and riboflavin and cataract extraction in women.
Design: Prospective cohort study beginning in 1980
with eight years of follow up.
Setting: 11 States of the United States.
Participants: Female registered nurses who were 45 to
67 years of age. 50,828 women were included in 1980 and others were added as
they became 45 years of age.
Main outcome measure: Incidence of extraction of
senile cataracts.
Results: 493 cataracts were extracted during 470,302
person years of follow up. Intake of carotene and vitamin A was inversely
associated with cataract: in multivariate analyses, women in the highest fifth
of total vitamin A intake (excluding supplements) had a 39% lower risk of
cataract relative to women in the lowest fifth (relative risk 0.61; 95%
confidence interval 0.45 to 0.81). Neither riboflavin nor dietary vitamins E or
C were associated with cataract in a multivariate analysis. Among specific food
items spinach ( rather than carrots, the greatest source of beta carotene) was
most consistently associated with a lower relative risk of cataract relative
risk. The risk of cataract was 45% lower among women who used vitamin C
supplements for 10 or more years (relative risk 0.55 (0.32 to 0.96)), but no
association was noted for multivitamin intake.
Conclusion: Dietary carotenoids, although not
necessarily beta carotene, and long term vitamin C supplementation may decrease
the risk of cataracts severe enough to require extraction.